منابع مشابه
IP3 receptors
What are they? Members of a family of intracellular ligand-gated ion channels that allow Ca2+ release from intracellular stores. The endoplasmic reticulum (ER), or specialised regions of it, contains ATP-driven Ca2+ pumps which generate a high Ca2+ concentration in the ER lumen. When inositol 1,4,5-trisphosphate (IP3) binds to IP3 receptors, the channel region of the receptor opens, allowing Ca...
متن کاملPlasma membrane IP3 receptors.
IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch-clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional IP3Rs in its plasma membrane. Only approx. ...
متن کاملIP(3) receptors, stress and apoptosis.
Inositol 1,4,5-trisphosphate (IP3) receptors are intracellular calcium channels that are able to release calcium from intracellular stores upon activation by IP3 and modulation by calcium. IP3 receptors are involved in variety of processes during physiological, but also in the pathophysiological states. Unraveling their regulation and function, especially under the pathological situations can r...
متن کاملRegulation of IP3 receptors by cyclic AMP
Ca2+ and cAMP are ubiquitous intracellular messengers and interactions between them are commonplace. Here the effects of cAMP on inositol 1,4,5-trisphosphate receptors (IP3Rs) are briefly reviewed. All three subtypes of IP3R are phosphorylated by cAMP-dependent protein kinase (PKA). This potentiates IP3-evoked Ca2+ release through IP3R1 and IP3R2, but probably has little effect on IP3R3. In add...
متن کاملA General Analysis of Single IP3 Receptors Modulated by Cytosolic Ca2+ and IP3
In this report, we remove the constraint of detailed balance and give a general discussion of the modulation of cytosolic Ca2+ and IP3 on the IP3R channel. By introducing the circulation decomposition theorem in stochastic process, the gating mechanism of single IP3R is neatly analyzed. Some remarkable differences are found to distinguish between equilibrium and non-equilibrium dynamics. Eviden...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2012
ISSN: 1338-4325
DOI: 10.4149/gpb_2012_014